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A Novel Compound with Leishmanicidal Activity

One new unsaturated amide named as Piplamide, N-isobutyl-19-(3’,4’-methylenedioxyphenyl)-2E,4E-nonadecadienamide, was isolated from the fruits of the Indian medicinal plant Piper longum by bioassay guided fractionation and isolation, using an in vitro promastigotes assay against of Leishmania donovani. The structure was elucidated on the basis of spectroscopic analysis. a) piplamide shows a very good antileishmanial activity against Leishmania donovani promastigotes

Sector: Biotechnology
Country: India
Area of Application:
a. Piplamide could be evaluated as prospective enzyme inhibitor and could provide lead structure for further optimization of activity for use in antileshmanial drug developement.
b. Piperlongimin A and piperlongimin B could provide lead structures for the development of novel anticancer therapeutics.
Keywords: Leishmanicidal, Cytotoxic, Piper longum, Piplamide
a. Piplamide shows a very good antilesihmanial activity against Leishmania donovani promastigotes.
b. piperlongimin A (2E-N-isobutyl-hexadecenamide) and piperlongimin B (2E-octadecenoylpiperidine) inhibited cell prolifeeration of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects.
Environmental aspects: Environment Friendly
Development Status: LaboratoryModel
Legal Protection: Patent
Technical specifications:
a. One new unsaturated amide named as Piplamide, N-isobutyl-19-(3',4'-methylenedioxyphenyl)-2E, 4E-nonadecadienamide, was isolated from the fruits of the Indian medicinal plant Piper longum by bioassa
Transfer Terms:
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  • Technical services
  • Technology Licensing
  • Research Partnerships
Target Countries:
  • Chile
  • China
  • India
  • Malaysia
  • Sri Lanka
  • Thailand
  • United States of America (the)
  • United Kingdom
Estimated cost (US$):
Your Contact Details:
Contact Person: NA
Address: Amity University Uttar Pradesh
Sector-125, Noida
City: Distt Gautam Buddha Nagar
Country: India
Zip/Pin Code: 201303

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