Identification and Uilization of Antibacterial Agents
The present technology provides a method of identifying the site of interaction between bacterial toxin and antitoxin polypeptides. The method includes A) Exposing toxin and antitoxin polypeptides of a toxin-antitoxin pair produced by the bacterial cell to a plurality of molecules; and B) Identifying a molecule of the plurality of molecules capable of preventing or disrupting binding between the antitoxin and the toxin polypeptides. It thus enables to identify or design novel antibiotics which target this site of interaction and thus enable bacterial cell killing. The present technology also provides a method of treating an infection of bacteria by preventing or disrupting binding between a toxin and antitoxin polypeptides of a toxin-antitoxin pair produced in the bacteria. The technology also provides a pharmaceutical composition for treating an infection of bacteria through an effective amount of an agent capable of preventing or disturbing binding between a toxin and antitoxin polypeptide.
Sector: Medical Technologies
Area of Application: medical industry
Keywords: antibacterial agents, antibiotics
Advantages: Safe and effective Alternate treatment to antibiotics.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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