A novel method of Methanone Preparation
The present technology provides a process for the preparation of methanone, the said process comprising steps of: (a) condensing a halo-quinoline with an a.-picolyl derivative in the presence of an organic solvent, a base and a phase transfer catalyst at -10 degree to +90 degree C. (b) adding an oxidizing agent to the reaction mixture of step (a) containing the acetonitrile derivative at -10 degree to +90 degree C. (c) cooling the reaction mixture of step (b) and neutralizing with any suitable acid followed by extraction with an organic solvent. (d) removing the organic solvent of step (c) and crystallizing the Methanone. The entire process described above is carried out in the same vessel, without the need to isolate the acetonitrile intermediate. The process is thus an improvement over all existing and known methods.
Sector: Pharmaceuticals
Country: India
Area of Application: medical industry, pharma industry.
Keywords: Methanone Preparation,Mefloquine,Methanone
Advantages: One pot process for the synthesis of Methanone compound. Method is safe and easy to follow. Methanone yield obtained (93-95%). Economical.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications:  
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):  
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Country: India
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