Economical Levobupivacaine Synthesis Process
The proposed technology suggests a novel method of producing levobupivacaine by catalytic asymmetric synthesis route. The method uses easily available synthons as the starting materials and avoids the use of expensive resolving agents in the synthesis process. This method achieves high chemical yield of final product levobupivacaine i.e. to the extent of 65 percent of overall yield and the final product is obtained in enantiomeric excess of >98 percent. The process involves fewer steps than the existing processes.
Area of Application: synthesis process, crystallization.
Keywords: synthesis process
Advantages: This novel method eliminates the requirement of costly resolving agents Process uses readily available, simple, achiral synthons as starting material Eliminates the need for recycling of unwanted isomer Catalytic asymmetric alkylation process creates a new chiral center using synthons such as protected glycinamide Process involves fewer steps Chiral catalyst is used in very small quantity to obtain levobupivacaine of desired chirality
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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