Researchers from Institute of Genomics and Integrative Biology (IGIB), India, have found a new target that can potentially be used for developing new antibiotics that will be effective against many bacteria. The new target is made of two proteins, which form a complex that is responsible for the formation of biofilm, that perform very important functions and are critical for bacterial ability to successfully infect humans.
The researchers have found the molecular signalling events that play a crucial role in biofilm formation in Bacillus anthracis, the causative agent of anthrax. The team found several proteins receive signals from PrkC protein. Using cutting edge genetics, molecular biology and proteomics techniques, they confirmed that GroEL was regulated by PrkC.
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