The Department of Biotechnology (DBT), Government of India, will soon begin research on nano-intervention in management of ophthalmic diseases aiming to advance research and provide innovations in various issues related to ophthalmic disorders. DBT’s initiative to begin research on nano-intervention in management of ophthalmic diseases holds significance as nanobiotechnology holds considerable promise to address various issues related to ophthalmic disorders such as glaucoma, diabetic retinopathy, age related macular degeneration.
It also covers other such diseases especially those affecting posterior segment of an eye. Nano enabled system and devices can find novel therapeutic solutions for crossing blood retina barrier and make sustained availability of drugs in desired therapeutic concertation in different compartments of eye. The DBT has invited proposals built upon innovative ideas in the areas of “Nano Enabled System and Devices for Ocular diseases” by undertaking studies including but not limited to the two areas.
A design and development of nano-enabled system for delivery of drugs in chronic diseases of eye for sustained delivery of drugs for chronic conditions – age related Macular Degeneration, Diabetic Retinopathy, Glaucoma; tissue specific targeting of drugs in ciliary body, trabecular network, bruch’s membrane/retinal pigment epithelial complex (sealing agents); crossing blood retina barrier; non-invasive nano formulations of existing drugs; delivery of gene/s for child blindness like Leber Congenital Amaurosis and Retinitis Pigmentosa; and cell based therapy.
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New initiative in ophthalmic disease management
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