A New Method for Cheaper and Longer Lasting Bioimplants
The technology is therefore aimed at addressing the various shortcomings associated with the existing implants thereby improving implant making processes. The present technology provides novel titanium based composite bioactive (biocompatible) material useful as prosthetic implant as against conventional processes where-in the bioactive phases, usually calcium phosphatic chemicals, is present on the surface of the bioinert Ti. The novel titanium based implant allows tissue growth deep into the composite as against theconventional Ti based surface-coated implants which enable only surface integration because of the presence of bioactive phase only on the surface allowing tissue growth only at the surface of the implant, limited to the thickness of the bioactive coated phase. The implant when implanted in place of a damaged bone, can locate itself securely at the implantation and enables through integration with the healthy bone, thus completely avoiding any possibility of the implant getting loosened. The Ti based biocompatible material is capable of extracting out biological HA from the body fluids hence it substitutes the need of synthetic HA. Titanium oxide and certain calcium phosphatic and chemicals, which get formed in the present invention, have the potential to precipitate out biological HA from body fluids. This fact is proved by immersing the implant in SBF (Simulated Body Fluids). In biological HA the sizes of individual particles are more uniform. In the context of longevity of the implant, it is better to have more amount of biological HA in the implant and reduce the amount of synthetic HA.Titanium base powders are mixed with powder precursors of calcium and phosphorus, blended, milled and compacted. These compacts when calcined at 600-1200°C under various atmospheres form in situ calciumphosphatic bioactive phases distributed uniformly in bioinert titanium phases. The calcined compacts are crushed, compacted to shape and vacuum sintered at 1000-1250°C to obtain appropriate interconnected porosity and strength. Immersion of the biocomposite in simulated body fluids, led to precipitation of bioactive phases like calcium hydroxyapatite, tricalcium phosphate, sodium calcium phosphate and calcium hydrogen phosphates on the surface, indicating biocompatibility of the implantable material having required interconnected porosity for facilitating tissue growth. The composite material thus developed by such process is noncytotoxic, has adequate corrosion properties, mechanical strength and can be used for orthopedic and other implants. What is the Novelty The bioactive phases are not directly added to Ti, but added in the form of salts of calcium and phosphorus which during processing, convert into different bioactive phases within the bio inert Ti in situ - thereby ensuring proximity of the bioactive phases thus formed with the Ti phase. In vitro-cytotoxicity tests were performed and it was confirmed that the biocomposite produced by the process of this technology is noncytotoxic.
Sector: Medical Technologies
Area of Application: medical industry.
Keywords: Lasting Bio implants
Advantages: Uniform and higher strength throughout the composite Bio-composite allows the growth of bone substitute material from the body fluids
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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