A Novel Compound with Leishmanicidal Activity
One new unsaturated amide named as Piplamide, N-isobutyl-19-(3’,4’-methylenedioxyphenyl)-2E,4E-nonadecadienamide, was isolated from the fruits of the Indian medicinal plant Piper longum by bioassay guided fractionation and isolation, using an in vitro promastigotes assay against of Leishmania donovani. The structure was elucidated on the basis of spectroscopic analysis. a) piplamide shows a very good antileishmanial activity against Leishmania donovani promastigotes
Sector: Biotechnology
Country: India
Area of Application: a. Piplamide could be evaluated as prospective enzyme inhibitor and could provide lead structure for further optimization of activity for use in antileshmanial drug developement. b. Piperlongimin A and piperlongimin B could provide lead structures for the development of novel anticancer therapeutics.
Keywords: Leishmanicidal, Cytotoxic, Piper longum, Piplamide
Advantages: a. Piplamide shows a very good antilesihmanial activity against Leishmania donovani promastigotes. b. piperlongimin A (2E-N-isobutyl-hexadecenamide) and piperlongimin B (2E-octadecenoylpiperidine) inhibited cell prolifeeration of human leukemia, HL-60 cell lines, and displayed major apoptosis-inducing effects.
Environmental aspects: Bio-Degradable and Environmental Friendly
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications: a. One new unsaturated amide named as Piplamide, N-isobutyl-19-(3',4'-methylenedioxyphenyl)-2E, 4E-nonadecadienamide, was isolated from the fruits of the Indian medicinal plant Piper longum by bioassa
Transfer Terms: Consultancy , Technical Services , Technology Licensing , Research Partnerships
Target Countries: Chile, China, India, Malaysia, Sri Lanka, Thailand, United States, United Kingdom
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