An Improved Process for Isolation and Purification of Lysergol from Ipomoeia hederacea seeds
The present invention discloses an improved method for isolation and purification of Lysergol from the seeds of Kaladana (Ipomoea hederacea), belonging to the Convulvulaceae family, Ipomoeae section. The method is a selective extraction by primary alcohol at a temperature in the range of 45-750 C. Lysergol is a compound that has been identified as a source of therapeutic value and commercial high value compound, used in the treatment of schizophrenia and motor disorders. It is also used in the synthesis of Lumilysergol and Nicergoline. The drug consisting of seeds, is locally used for its aperient action.
Sector: Other Technologies n.e.c.
Area of Application: Lysergol is a compound that has been identified as a source of therapeutic value and commercial high value compound, used in the treatment of schizophrenia and motor disorders. It is also used in the synthesis of Lumilysergol and Nicergoline. It is an alkaloid, of ergolic structure. Its use in traditional medicine dates back to the modern medicines of 19th century. Some less known but promising traditional formulations of Chhatisgarh, India, are based on the kaladana as main ingredient. The drug consisting of seed is locally used for its aperient action whereas the powder is used as an antipyretic.
Keywords: Kaladana, Extraction, Purification, TLC, HPLC, Lysergol.
Advantages: (i). The main advantage of the present invention is to provide an eco-friendly and hygienic method for commercial manufacturing of Lysergol. (ii). Another advantage of the present invention is to develop economically beneficial manufacturing process by cost cutting. (iii). The present invention is to avoid direct human exposure with hazardous chemicals solvents. (iv). This invention is to reduce the long operation span. (v). Still another advantage of the present invention is to provide a method for purification of Lysergol with purity up-to 99.2%. (vi). This invention is to provide final product with impurity less than 0.5%.
Environmental aspects: Healthcare
Development Status: Laboratory Model
Technical specifications: Lysergol with defined purity and impurity profile , assay by HPLC.
Transfer Terms: Consultancy , Technical Services , Technology Licensing , Research Partnerships
Target Countries: World Wide
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