An Improved Method for Manufacturing of Bacopa monnieri Extract
The present invention discloses a method for obtaining standardized extract of Bacopa monnieri rich in bacosides not less than 40% in free flowing powder form. The method of extraction is with reduced method steps and time. The Bacopa monnieri extract comprising bacosides, not less than 40% have applications in pharmaceutical formulations for the treatment of various nervous disorders and nervous ailments.
Sector: Other Technologies n.e.c.
Area of Application: Bacoside rich leaf extract of Bacopa monniera shows a therapeutic potential of in improving the memory functions in hypobaric conditions. Bacoside administration was seen to enhance learning ability in rats along with augmentation in memory retrieval and prevention of dendritic atrophy following hypoxic exposure. In addition, it decreased oxidative stress, plasma corticosterone levels and neuronal degeneration. Bacoside administration also increased cytochrome c oxidase activity along with a concomitant increase in ATP levels. Hence, administration of bacosides could be a useful therapeutic strategy in ameliorating hypobaric hypoxia induced cognitive dysfunctions and other related neurological disorders (Sunil Kumar Hota, Kalpana Barhwal, Iswar Baitharu, Dipti Prasad, Shashi Bala Singh and Govindasamy Ilavazhagan, 2009, Bacopa monniera leaf extract ameliorates hypobaric hypoxia induced spatial memory impairment,, Neurobiology of Disease, Volume 34, Issue 1, Pages 23-39) The neuroprotective role of B. monnieri extract in alteration of glutamate receptor binding and gene expression of NMDA R1 in hippocampus of temporal lobe epileptic rats has been demonstrated. In association with pilocarpine-induced epilepsy, there was significant down regulation of NMDA R1 gene expression and glutamate receptor binding without any change in its affinity. B. monnieri treatment of epileptic rats significantly reversed the expression of NMDA R1 and glutamate receptor binding alterations to near-control levels. Also, in the epileptic rats, we measured a significant increase in the activity of glutamate dehydrogenase, which neared the control level after B. monnieri treatment.
Keywords: Bacopa monnieri, Extraction, Analysis, Saponins, Memory enhancer
Advantages: (i). The principal advantage the present invention is to provide an improved method with reduced process steps for obtaining Bacopa monnieri extract. (ii). Another advantage of the present invention is to obtain a standardized extract of Bacopa monnieri enriched with a defined percentage of bacoside. (iii). The standardized extract of Bacopa monnieri comprising of synergistic ingredients is useful for therapeutical applications. (iv). The standardized extract of Bacopa monnieri in an easy to use free flowing powder form. (v). In the present innovation use of hazardous solvents in the extraction process is avoided. (vi). The invention is for extraction of bacoside from Bacopa monnieri which is economical and is with reduced process time.
Development Status: Laboratory Model
Technical specifications: Free flowing powder with defined contents.
Transfer Terms: Consultancy , Technical Services , Technology Licensing , Others
Target Countries: World Wide
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