A Novel Process Foramides Synthesisamides Synthesis
The present technology provides with an amidation reaction of unprotected a-amino acids in water under neutral conditions with various aliphatic, aromatic and heteroaromatic amines in the presence of coupling reagent l,l'-carbonyldiimidazole (CDI) at ambient temperature to obtain the corresponding a-amino acid amides. This method offers a novel way for amidation of unprotected a-amino acids in one pot reaction. The said amidation reaction can be performed on free as well as hydrochloride salts of amino acids and the sidechain functionality was found to be relatively unaffected by the reagent and reaction conditions. Moreover,the reaction was found to be stereo-conservative in nature, and no apparent racemization of the final products was observed.
Area of Application: Medical industry, Pharmaceutical industry.
Keywords: amides synthesis,amides synthesis
Advantages: Process is novel and stereo-conservative in nature. Use of unprotected amino acids in a one-step amidation reaction increases the yield comprehensively and decreases the cost effectively. Process can be performed in water that offers environmental and economic benefits over the conventional organic solvents. Process is applicable to a wide array of aliphatic, aromatic and heteroaromatic primary amines.
Environmental aspects: Not Applicable
Development Status: Laboratory Model
Legal Protection: Patent in Progress
Transfer Terms: Technology Licensing
Target Countries: India
Estimated cost (US$):
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