Biomaterials from Regenerated Silk Fibroin
NCL scientists have developed various processes for producing 3D porous biomaterials from regenerated silk fibroin (RSF). Our process for the accelerated gelation of RSF- resulting in a porous structure lowers the gelation time to a few hours instead of several days. The protein concentration can be between 0.1- 40%. It works in a broad pH range of 5 – 7.5, within temperatures ranging from 20-70°C. Another process using electrospinning of RSF from an aqueous solution, forms 3D porous structures (like non-woven mats) which have various biomedical applications. Surface modification of such biomaterials for improved performance is currently under progress.
Sector: Health care technology
Country: India
Area of Application: · In tissue engineering- as bio-degradable bioabsorbable scaffolds (due to lower inflammatory and superior mechanical properties) and damaged tissue regeneration (For ex. bone, nerves, ligament, etc) · In wound healing bandages (provides a moist environment to facilitate re-epithiliazation, re-modeling of connective tissues and collagenization) · As controlled drug delivery vehicles · Silk fibroin peptides are used in cosmetics due to their glossy, flexible, elastic coating power, easy spreading and adhesion
Keywords: biomedical scaffolds, tissue engineering, regenerated silk fibroin, biodegradable, 3D porous biomaterials
Advantages: · Free of microbial growth (superior performance of implants, lower toxicity) · Shorter gelation time opens-up the potential spectrum of applications of the materials developed using this method · Process is cheaper and faster (aqueous solution used instead of organic solventeliminates several intermediate steps) · Implant that could be reproduced with great consistency and quality · Wide range of pore sizes: 1-10 microns
Environmental aspects:
Development Status: Laboratory Model
Legal Protection: Patent
Technical specifications:
Transfer Terms: Technology Licensing
Target Countries:
Estimated cost (US$):
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Contact Person: National Chemical Laboratory, CSIR
Address: A208, PAML Building, National Chemical Laboratory Dr Homi Bhabha Road,
City: Pune
Country: India
Zip/Pin Code: 411007
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