Johnson & Johnson’s Janssen Pharmaceuticals, Belgium, has licensed Denmark based Bavarian Nordic’s Modified Vaccinia Ankara-Bavarian Nordic (MVA-BN®) technology toward development of new vaccines for human immunodeficiency virus (HIV) and hepatitis B virus (HBV), under an up-to-$879 million agreement that expands the companies’ ongoing collaboration.
Janssen Pharmaceuticals, part of J&J’s Janssen Pharmaceutical Companies, has gained exclusive rights to MVA-BN, which it will combine with Janssen’s own AdVac® technology platform as the companies develop new vaccines for HIV and HBV. The agreement was announced yesterday. Three days earlier, J&J trumpeted positive first-in-human clinical data generated by Janssen for its investigational HIV-1 vaccine regimen.
Mosaic-based vaccines contain immunogens created using genes from different HIV subtypes responsible for HIV-1 infections worldwide. The immunogens are delivered through viral vectors, including Janssen’s AdVac technology based on adenovirus serotype 26 (Ad26). The viral vectors are combined with other components, such as soluble proteins, to form mosaic-based prime-boost vaccine regimens designed to produce stronger and longer-lasting immunity to HIV.
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Vaccine collaboration for HIV, Hepatitis B
VATIS UPDATE Part
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