VATIS UPDATE Article

The Helmholtz Zentrum München, Germany, has published results of their largest genome-wide association study (GWAS) on proteomics to date. An international team of scientists has reported 539 associations between protein levels and genetic variants. These associations overlap with risk genes for 42 complex diseases. GWAS provide an opportunity to associate concentration changes in certain proteins or metabolic products with gene loci. Knowledge of these genes makes it possible to establish connections to complex diseases.

Scientists utilize the fact that to date, hundreds of associations between genetic variants and complex diseases have been demonstrated. These associations are immensely important because they do help uncover the underlying molecular mechanisms. “In the world’s largest proteomics GWAS to date, we worked with colleagues to examine blood samples from 1,000 participants in the KORA study,” said Dr. Gabi Kastenmüller. The team quantified a total of 1,100 proteins.

“We found 539 independent associations between protein levels and genetic variants,” said Dr. Christian Gieger, at the Helmholtz Zentrum München. These overlap with genetic risk variants for 42 complex conditions, such as cardiovascular diseases and Alzheimer’s disease. “Our results provide new insights into the biological processes that are influenced by a very wide range of complex diseases and that can be used as a basis for the development of new strategies to predict and prevent these diseases,” Gieger added.